Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50101339
Substrate
n/a
Meas. Tech.
ChEBML_45058
Ki
40±n/a nM
Citation
 Mincione, F; Starnotti, M; Menabuoni, L; Scozzafava, A; Casini, A; Supuran, CT Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Bioorg Med Chem Lett 11:1787-91 (2001) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50101339
Synonyms:
(S)-3-(3H-Imidazol-4-yl)-2-(4-sulfamoyl-benzoylamino)-propionic acid | CHEMBL300265
Type:
Small organic molecule
Emp. Form.:
C13H14N4O5S
Mol. Mass.:
338.339
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O
Structure:
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