Reaction Details
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4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Ligand
BDBM50101907
Substrate
n/a
Meas. Tech.
ChEBML_69264
IC50
>500000±n/a nM
Citation
Schuster, M; Blechert, S Inhibition of fucosyltransferase V by a GDP-Azasugar. Bioorg Med Chem Lett 11:1809-11 (2001) [PubMed] Article More Info.:
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Synonyms:
FUT5 | FUT5_HUMAN | Fucosyltransferase 5
Type:
PROTEIN
Mol. Mass.:
43016.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_69264
Residue:
374
Sequence:
MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSSVYPQADAVIVHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQQESRYQTVRSIAAWFT
Inhibitor
Name:
BDBM50101907
Synonyms:
({[(2R,3S,4R,5R)-5-(2-azaniumyl-6-hydroxy-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)(methyl)phosphinate | GDP-Azasugar analogue
Type:
Small organic molecule
Emp. Form.:
C11H16N5O10P2
Mol. Mass.:
440.2203
SMILES:
CP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Structure:
