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Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50128892
Substrate
n/a
Meas. Tech.
ChEBML_144315
IC50
2100±n/a nM
Citation
 Taguchi, M; Sugimoto, K; Goda, K; Akama, T; Yamamoto, K; Suzuki, T; Tomishima, Y; Nishiguchi, M; Arai, K; Takahashi, K; Kobori, T Sphingomyelin analogues as inhibitors of sphingomyelinase. Bioorg Med Chem Lett 13:1963-6 (2003) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
NSMA_RAT | Neutral sphingomyelinase | Smpd2
Type:
PROTEIN
Mol. Mass.:
47651.22
Organism:
Rattus norvegicus
Description:
ChEMBL_611790
Residue:
422
Sequence:
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
  
Inhibitor
Name:
BDBM50128892
Synonyms:
CHEMBL62020 | Pyridin-3-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,2-dimethyl-propionylamino)-3-hydroxy-octadec-4-enyl ester
Type:
Small organic molecule
Emp. Form.:
C30H51N3O4
Mol. Mass.:
517.7436
SMILES:
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](COC(=O)NCc1cccnc1)NC(=O)C(C)(C)C
Structure:
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