Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50146289
Substrate
n/a
Meas. Tech.
ChEMBL_214261 (CHEMBL818587)
Ki
13±n/a nM
Citation
Matthews, JM; Hoekstra, WJ; Dyatkin, AB; Hecker, LR; Hlasta, DJ; Poulter, BL; Andrade-Gordon, P; de Garavilla, L; Demarest, KT; Ericson, E; Gunnet, JW; Hageman, W; Look, R; Moore, JB; Reynolds, CH; Maryanoff, BE Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates. Bioorg Med Chem Lett 14:2747-52 (2004) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Human
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Inhibitor
Name:
BDBM50146289
Synonyms:
4-Hydroxy-biphenyl-2-carboxylic acid [3-chloro-4-((S)-3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cycloheptene-10-carbonyl)-phenyl]-amide | CHEMBL329141
Type:
Small organic molecule
Emp. Form.:
C32H28ClN3O4
Mol. Mass.:
554.035
SMILES:
Oc1ccc(-c2ccccc2)c(c1)C(=O)Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc23)c(Cl)c1