Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50022831
Substrate
n/a
Meas. Tech.
ChEMBL_54567 (CHEMBL664881)
KON
6800000 M-1s-1
Citation
 Taira, K; Benkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem 31:129-37 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
dfrA17 | Dihydrofolate reductase (F31V)
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50022831
Synonyms:
6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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