Reaction Details Report a problem with these data
Target
Aromatase
Ligand
BDBM50014765
Substrate
n/a
Meas. Tech.
ChEBML_51212
EC50
>5000±n/a nM
Citation
 Jones, CD; Winter, MA; Hirsch, KS; Stamm, N; Taylor, HM; Holden, HE; Davenport, JD; Krumkalns, EV; Suhr, RG Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups. J Med Chem 33:416-29 (1990) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50014765
Synonyms:
1-[Bis-(4-chloro-phenyl)-methyl]-piperidine | CHEMBL335252
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2N
Mol. Mass.:
320.256
SMILES:
Clc1ccc(cc1)C(N1CCCCC1)c1ccc(Cl)cc1
Structure:
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