Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM50001562
Substrate
n/a
Meas. Tech.
ChEBML_69323
IC50
240±n/a nM
Citation
 Melikian, ASchlewer, GChambon, JPWermuth, CG Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. J Med Chem 35:4092-7 (1992) [PubMed]  Article
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
GABA receptor alpha-1 subunit | GABA-A receptor; anion channel
Type:
PROTEIN
Mol. Mass.:
51770.21
Organism:
Mus musculus
Description:
ChEMBL_69323
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM50001562
Synonyms:
5-(6-Imino-3-phenyl-6H-pyridazin-1-ylmethyl)-isoxazol-3-ol; hydrobromide | CHEMBL552953
Type:
Small organic molecule
Emp. Form.:
C14H12N4O2
Mol. Mass.:
268.2707
SMILES:
N=c1ccc(nn1Cc1cc(=O)[nH]o1)-c1ccccc1
Structure:
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