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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50013111
Substrate
n/a
Meas. Tech.
ChEMBL_197124 (CHEMBL801614)
EC50
50±n/a nM
Citation
 Sergheraert, C; Pierlot, C; Tartar, A; Henin, Y; Lemaitre, M Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs. J Med Chem 36:826-30 (1993) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
Reverse transcriptase/RNaseH | Human immunodeficiency virus type 1 reverse transcriptase | HIV-1 Reverse Transcriptase RNase H
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50013111
Synonyms:
2',3'-didehydro-3'-deoxythymidine | 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 3'-deoxy-2',3'-didehydrothymidine | 1-((2R,5S)-5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | cid_5155 | Zerit | 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (ddeThd) | Zerit xr | 1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | d4T | BMY-27857 | CHEMBL991 | 3'-deoxy-2'-thymidine | 2',3'-dideoxy-2',3'-didehydrothymidine | cid_18283 | STAVUDINE
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cn([C@@H]2O[C@H](CO)C=C2)c(=O)[nH]c1=O |r,c:9|
Structure:
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