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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50044911
Substrate
n/a
Meas. Tech.
ChEMBL_197124 (CHEMBL801614)
EC50
40±n/a nM
Citation
 Sergheraert, C; Pierlot, C; Tartar, A; Henin, Y; Lemaitre, M Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs. J Med Chem 36:826-30 (1993) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
Reverse transcriptase/RNaseH | Human immunodeficiency virus type 1 reverse transcriptase | HIV-1 Reverse Transcriptase RNase H
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50044911
Synonyms:
Heptadeca-9,12,15-trienoic acid 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester | CHEMBL170331
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C\C=C\C\C=C\C\C=C\CCCCCCCC(=O)OCC1OC(C=C1)n1cc(C)c(=O)[nH]c1=O |c:23|
Structure:
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