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Target
D(2) dopamine receptor
Ligand
BDBM50051280
Substrate
n/a
Meas. Tech.
ChEMBL_61578 (CHEMBL675092)
IC50
0.62±n/a nM
Citation
 Norman, MH; Rigdon, GC; Hall, WR; Navas, F Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. J Med Chem 39:1172-88 (1996) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50051280
Synonyms:
CHEMBL544436 | N-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-3-bromo-2-hydroxy-6-methoxy-benzamide; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C23H27BrN4O3S
Mol. Mass.:
519.454
SMILES:
COc1ccc(Br)c(O)c1C(=O)NCCCCN1CCN(CC1)c1nsc2ccccc12
Structure:
Search PDB for entries with ligand similarity: