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Target
Neprilysin
Ligand
BDBM50064096
Substrate
n/a
Meas. Tech.
ChEMBL_144609 (CHEMBL751028)
IC50
14±n/a nM
Citation
 Wallace, EM; Moliterni, JA; Moskal, MA; Neubert, AD; Marcopulos, N; Stamford, LB; Trapani, AJ; Savage, P; Chou, M; Jeng, AY Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme. J Med Chem 41:1513-23 (1998) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85505.38
Organism:
Homo sapiens (Human)
Description:
P08473
Residue:
750
Sequence:
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
  
Inhibitor
Name:
BDBM50064096
Synonyms:
CHEMBL40028 | {[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetrazol-5-yl)-but-3-ynylamino]-methyl}-phosphonic acid | {[4-(2-Fluoro-phenyl)-1-(1H-tetrazol-5-yl)-but-3-ynylamino]-methyl}-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H13FN5O3P
Mol. Mass.:
325.2355
SMILES:
OP(O)(=O)CN[C@@H](CC#Cc1ccccc1F)c1nnn[nH]1
Structure:
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