Reaction Details Report a problem with these data
Target
Spermine synthase
Ligand
BDBM50095449
Substrate
n/a
Meas. Tech.
ChEMBL_223918 (CHEMBL845254)
IC50
20±n/a nM
Citation
 Casero, RA; Woster, PM Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem 44:1-26 (2001) [PubMed]  Article 
Target
Name:
Spermine synthase
Synonyms:
SPMSY | Spermidine aminopropyltransferase | SPSY_HUMAN | SMS
Type:
PROTEIN
Mol. Mass.:
41254.14
Organism:
Human
Description:
ChEMBL_223918
Residue:
366
Sequence:
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
  
Inhibitor
Name:
BDBM50095449
Synonyms:
2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexylsulfanylmethyl]-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol | CHEMBL315995
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NCCCNCCCCCC(CCN)SC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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