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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50101672
Substrate
n/a
Meas. Tech.
ChEMBL_221650 (CHEMBL823227)
Kd
23000±n/a nM
Citation
Proudfoot, JR; Betageri, R; Cardozo, M; Gilmore, TA; Glynn, S; Hickey, ER; Jakes, S; Kabcenell, A; Kirrane, TM; Tibolla, AK; Lukas, S; Patel, UR; Sharma, R; Yazdanian, M; Moss, N; Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain. J Med Chem 44:2421-31 (2001) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
Inhibitor
Name:
BDBM50101672
Synonyms:
CHEMBL312396 | {4-[2-[1-(4-Methoxy-benzyl)-2-oxo-2,3-dihydro-pyridin-3-ylcarbamoyl]-2-(2-naphthalen-1-yl-acetylamino)-ethyl]-phenyl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C36H33N3O6
Mol. Mass.:
603.6637
SMILES:
COc1ccc(Cn2cccc(NC(=O)C(Cc3ccc(CC(O)=O)cc3)NC(=O)Cc3cccc4ccccc34)c2=O)cc1