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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50077211
Substrate
n/a
Meas. Tech.
ChEMBL_221650 (CHEMBL823227)
Kd
5000±n/a nM
Citation
 Proudfoot, JR; Betageri, R; Cardozo, M; Gilmore, TA; Glynn, S; Hickey, ER; Jakes, S; Kabcenell, A; Kirrane, TM; Tibolla, AK; Lukas, S; Patel, UR; Sharma, R; Yazdanian, M; Moss, N; Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain. J Med Chem 44:2421-31 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50077211
Synonyms:
(S)-4-[(S)-3-(4-Carboxymethyl-phenyl)-2-(2-naphthalen-1-yl-acetylamino)-propionylamino]-4-(4-methoxy-benzylcarbamoyl)-butyric acid | 4-[3-(4-Carboxymethyl-phenyl)-2-(2-naphthalen-1-yl-acetylamino)-propionylamino]-4-(4-methoxy-benzylcarbamoyl)-butyric acid | CHEMBL50913
Type:
Small organic molecule
Emp. Form.:
C36H37N3O8
Mol. Mass.:
639.6943
SMILES:
COc1ccc(CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccc(CC(O)=O)cc2)NC(=O)Cc2cccc3ccccc23)cc1
Structure:
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