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Target
Bcl-2-like protein 1
Ligand
BDBM50088360
Substrate
n/a
Meas. Tech.
ChEMBL_38727 (CHEMBL647263)
IC50
2200±n/a nM
Citation
 Kitada, S; Leone, M; Sareth, S; Zhai, D; Reed, JC; Pellecchia, M Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 46:4259-64 (2003) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50088360
Synonyms:
2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,3,4,6-tetrahydroxy-5H-benzocycloheptene-5-one | 2,3,4,6-tetrahydroxybenzocyclohepten-5-one | CHEMBL66953 | Hit compound, 2 | Purpurogallin | purpurogalline
Type:
Small organic molecule
Emp. Form.:
C11H8O5
Mol. Mass.:
220.1782
SMILES:
Oc1cc2cccc(O)c(=O)c2c(O)c1O
Structure:
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