Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50145712
Substrate
n/a
Meas. Tech.
ChEMBL_304230 (CHEMBL829769)
EC50
1625±n/a nM
Citation
 Wang, M; Winneroski, LL; Ardecky, RJ; Babine, RE; Brooks, DA; Etgen, GJ; Hutchison, DR; Kauffman, RF; Kunkel, A; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, MK; Rito, CJ; Rungta, DK; Tripp, AE; Wilson, SB; Xu, Y; Zink, RW; McCarthy, JR Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis. Bioorg Med Chem Lett 14:6113-6 (2004) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Ppara | Nr1c1 | Ppar | Peroxisome Proliferator-Activated Receptor alpha
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mouse
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50145712
Synonyms:
2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid | CHEMBL82034
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1oc(nc1CCOc1ccc(CC(C)(Oc2ccccc2)C(O)=O)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: