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Target
RNA-directed RNA polymerase
Ligand
BDBM50157169
Substrate
n/a
Meas. Tech.
ChEMBL_306368 (CHEMBL829165)
IC50
3100±n/a nM
Citation
 Shipps, GW; Deng, Y; Wang, T; Popovici-Muller, J; Curran, PJ; Rosner, KE; Cooper, AB; Girijavallabhan, V; Butkiewicz, N; Cable, M Aminothiazole inhibitors of HCV RNA polymerase. Bioorg Med Chem Lett 15:115-9 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50157169
Synonyms:
2-{Cyclohexyl-[4-(3-methoxy-phenoxy)-benzoyl]-amino}-thiazole-5-carboxylic acid | CHEMBL182462
Type:
Small organic molecule
Emp. Form.:
C24H24N2O5S
Mol. Mass.:
452.523
SMILES:
COc1cccc(Oc2ccc(cc2)C(=O)N(C2CCCCC2)c2ncc(s2)C(O)=O)c1
Structure:
Search PDB for entries with ligand similarity: