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Target
RNA-directed RNA polymerase
Ligand
BDBM50157182
Substrate
n/a
Meas. Tech.
ChEMBL_306368 (CHEMBL829165)
IC50
6500±n/a nM
Citation
 Shipps, GW; Deng, Y; Wang, T; Popovici-Muller, J; Curran, PJ; Rosner, KE; Cooper, AB; Girijavallabhan, V; Butkiewicz, N; Cable, M Aminothiazole inhibitors of HCV RNA polymerase. Bioorg Med Chem Lett 15:115-9 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50157182
Synonyms:
2-[(4-Benzyloxy-benzoyl)-cyclohexyl-amino]-thiazole-5-carboxylic acid | CHEMBL361207
Type:
Small organic molecule
Emp. Form.:
C24H24N2O4S
Mol. Mass.:
436.523
SMILES:
OC(=O)c1cnc(s1)N(C1CCCCC1)C(=O)c1ccc(OCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: