Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM50155855
Substrate
n/a
Meas. Tech.
ChEMBL_306665 (CHEMBL831438)
IC50
2680±n/a nM
Citation
 Héja, LKovács, ISzárics, EIncze, MTemesváriné-Major, EDörnyei, GPeredy-Kajtár, MGács-Baitz, ESzántay, CKardos, J Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem 47:5620-9 (2004) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | Solute carrier family 6 member 1 | SC6A1_RAT | Slc6a1 | Gabt1 | Gat-1 | Gat1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Rat
Description:
ChEMBL_1472611
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM50155855
Synonyms:
(Z)-4-(Ethoxycarbonylmethyl-methyl-amino)-3-phenyl-pent-2-enoic acid ethyl ester | CHEMBL366270
Type:
Small organic molecule
Emp. Form.:
C18H25NO4
Mol. Mass.:
319.40
SMILES:
CCOC(=O)/C=C(/c1ccccc1)C(C)N(C)CC(=O)OCC
Structure:
Search PDB for entries with ligand similarity: