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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM24183
Substrate
n/a
Meas. Tech.
ChEMBL_306677 (CHEMBL830011)
IC50
2600±n/a nM
Citation
 Héja, L; Kovács, I; Szárics, E; Incze, M; Temesváriné-Major, E; Dörnyei, G; Peredy-Kajtár, M; Gács-Baitz, E; Szántay, C; Kardos, J Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem 47:5620-9 (2004) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | Solute carrier family 6 member 1 | SC6A1_RAT | Slc6a1 | Gabt1 | Gat-1 | Gat1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Rat
Description:
ChEMBL_1472611
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM24183
Synonyms:
4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-Aminobutyric acid | GABA | CHEMBL96 | 4-aminobutanoic acid | Aminalon | [3H]GABA
Type:
Radiolabeled ligand
Emp. Form.:
C4H9NO2
Mol. Mass.:
103.12
SMILES:
NCCCC(=O)O
Structure:
Search PDB for entries with ligand similarity: