Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1F
Ligand
BDBM50159175
Substrate
n/a
Meas. Tech.
ChEMBL_303711 (CHEMBL829046)
Ki
12.3±n/a nM
Citation
 Cole, DC; Lennox, WJ; Lombardi, S; Ellingboe, JW; Bernotas, RC; Tawa, GJ; Mazandarani, H; Smith, DL; Zhang, G; Coupet, J; Schechter, LE Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem 48:353-6 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1F
Synonyms:
5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.68
Organism:
Homo sapiens (Human)
Description:
5-HT1F HTR1F HUMAN::P30939
Residue:
366
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
  
Inhibitor
Name:
BDBM50159175
Synonyms:
2-Chloro-N-(3-(R)-1-pyrrolidin-2-ylmethyl-1H-indol-5-yl)-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3O2S
Mol. Mass.:
389.899
SMILES:
Clc1ccccc1S(=O)(=O)Nc1ccc2[nH]cc(CC3CCCN3)c2c1
Structure:
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