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Target
Amiloride-sensitive amine oxidase [copper-containing]
Ligand
BDBM50161149
Substrate
n/a
Meas. Tech.
ChEMBL_306517 (CHEMBL828122)
IC50
1000±n/a nM
Citation
 Bertini, V; Buffoni, F; Ignesti, G; Picci, N; Trombino, S; Iemma, F; Alfei, S; Pocci, M; Lucchesini, F; De Munno, A Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases. J Med Chem 48:664-70 (2005) [PubMed]  Article 
Target
Name:
Amiloride-sensitive amine oxidase [copper-containing]
Synonyms:
ABP | ABP1 | AOC1 | AOC1_HUMAN | Amiloride-binding protein | DAO | DAO1 | Diamine oxidase | Diamine oxidase (DAO) | Histaminase | KAO | Kidney amine oxidase
Type:
Protein
Mol. Mass.:
85387.64
Organism:
Homo sapiens (Human)
Description:
P19801
Residue:
751
Sequence:
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
  
Inhibitor
Name:
BDBM50161149
Synonyms:
4-(aminomethyl)-N-isopropyl-5-[isopropyl(methyl)-lambda~5~-azanyl]pyridin-3-amine dihydrochloride | CHEMBL537405
Type:
Small organic molecule
Emp. Form.:
C13H24N4
Mol. Mass.:
236.3565
SMILES:
CC(C)Nc1cncc(N(C)C(C)C)c1CN
Structure:
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