Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50174003
Substrate
n/a
Meas. Tech.
ChEMBL_326849 (CHEMBL860444)
Ki
4460±n/a nM
Citation
 Arora, J; Bordeleau, M; Dube, L; Jarvie, K; Mazzocco, L; Peragine, J; Tehim, A; Egle, I N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor. Bioorg Med Chem Lett 15:5253-6 (2005) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50174003
Synonyms:
(S)-N-(1-(3-methoxybenzyl)pyrrolidin-3-yl)-4-(thiophen-2-yl)benzamide | CHEMBL427555
Type:
Small organic molecule
Emp. Form.:
C23H24N2O2S
Mol. Mass.:
392.514
SMILES:
COc1cccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)c1
Structure:
Search PDB for entries with ligand similarity: