Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50152303
Substrate
n/a
Meas. Tech.
ChEMBL_326846 (CHEMBL860441)
Ki
1.5±n/a nM
Citation
 Arora, J; Bordeleau, M; Dube, L; Jarvie, K; Mazzocco, L; Peragine, J; Tehim, A; Egle, I N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor. Bioorg Med Chem Lett 15:5253-6 (2005) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50152303
Synonyms:
CHEMBL361035 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-thiophen-2-yl-benzamide | N-((S)-1-benzylpyrrolidin-3-yl)-3-(thiophen-2-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C22H22N2OS
Mol. Mass.:
362.488
SMILES:
O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: