Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50176706
Substrate
n/a
Meas. Tech.
ChEMBL_327856 (CHEMBL863986)
Ki
4±n/a nM
Citation
 Starck, JPTalaga, PQuéré, LCollart, PChristophe, BLo Brutto, PJadot, SChimmanamada, DZanda, MWagner, AMioskowski, CMassingham, RGuyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50176706
Synonyms:
1-(6-fluoropyridin-3-yl)-3-(3-methoxyquinuclidin-3-yl)-1-phenylprop-2-yn-1-ol | CHEMBL427013
Type:
Small organic molecule
Emp. Form.:
C22H23FN2O2
Mol. Mass.:
366.4286
SMILES:
COC1(CN2CCC1CC2)C#CC(O)(c1ccccc1)c1ccc(F)nc1 |THB:1:2:5.6:9.8,(7.82,-23.84,;9.35,-23.8,;10.15,-25.13,;10.72,-26.4,;12.01,-25.35,;13.49,-25.58,;12.85,-24.32,;11.39,-24.11,;11.01,-22.52,;11.74,-23.46,;8.82,-25.91,;7.5,-26.7,;6.17,-27.49,;5.39,-26.17,;4.85,-28.28,;3.5,-27.53,;2.18,-28.31,;2.2,-29.85,;3.55,-30.61,;4.87,-29.82,;6.96,-28.81,;8.48,-28.79,;9.27,-30.12,;8.52,-31.45,;9.31,-32.77,;6.98,-31.47,;6.19,-30.16,)|
Structure:
Search PDB for entries with ligand similarity: