Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50176717
Substrate
n/a
Meas. Tech.
ChEMBL_327856 (CHEMBL863986)
Ki
25±n/a nM
Citation
 Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50176717
Synonyms:
1-(3-methoxyquinuclidin-3-yl)-3-phenylhept-1-yn-3-ol | CHEMBL200416
Type:
Small organic molecule
Emp. Form.:
C21H29NO2
Mol. Mass.:
327.4605
SMILES:
CCCCC(O)(C#CC1(CN2CCC1CC2)OC)c1ccccc1 |THB:16:8:11.12:15.14,(25.15,-12.89,;23.66,-12.49,;23.27,-11,;24.36,-9.92,;23.96,-8.43,;23.57,-6.94,;25.45,-8.03,;26.94,-7.64,;28.44,-7.24,;28.64,-8.62,;30.17,-7.96,;31.54,-8.59,;31.26,-7.2,;29.91,-6.6,;29.98,-4.96,;30.42,-6.07,;28.03,-5.75,;26.54,-5.36,;22.47,-8.83,;21.38,-7.73,;19.89,-8.13,;19.49,-9.62,;20.58,-10.72,;22.07,-10.31,)|
Structure:
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