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Target
Metabotropic glutamate receptor 7
Ligand
BDBM50175073
Substrate
n/a
Meas. Tech.
ChEMBL_329055 (CHEMBL863304)
EC50
>1000000±n/a nM
Citation
 Amori, L; Serpi, M; Marinozzi, M; Costantino, G; Diaz, MG; Hermit, MB; Thomsen, C; Pellicciari, R Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Bioorg Med Chem Lett 16:196-9 (2005) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 7
Synonyms:
GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
102262.98
Organism:
Homo sapiens (Human)
Description:
Q14831
Residue:
915
Sequence:
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
  
Inhibitor
Name:
BDBM50175073
Synonyms:
(S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acetic acid | CHEMBL199626
Type:
Small organic molecule
Emp. Form.:
C5H10NO5P
Mol. Mass.:
195.1104
SMILES:
N[C@@H]([C@@H]1C[C@H]1P(O)(O)=O)C(O)=O
Structure:
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