Target
Translocator protein
Ligand
BDBM50185959
Substrate
n/a
Meas. Tech.
ChEMBL_352426 (CHEMBL859957)
Ki
0.10±n/a nM
Citation
 Zhang, MROgawa, MMaeda, JIto, TNoguchi, JKumata, KOkauchi, TSuhara, TSuzuki, K [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. J Med Chem 49:2735-42 (2006) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50185959
Synonyms:
CHEMBL381602 | N-(2-ethoxybenzyl)-N-(4-chloro-2-phenoxyphenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C23H22ClNO3
Mol. Mass.:
395.879
SMILES:
CCOc1ccccc1CN(C(C)=O)c1ccc(Cl)cc1Oc1ccccc1
Structure:
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