Reaction Details
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Type-2 angiotensin II receptor
Ligand
BDBM50195696
Substrate
n/a
Meas. Tech.
ChEMBL_414989 (CHEMBL909478)
Ki
53.1±n/a nM
Citation
Rosenström, U; Sköld, C; Lindeberg, G; Botros, M; Nyberg, F; Karlén, A; Hallberg, A Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors. J Med Chem 49:6133-7 (2006) [PubMed] Article More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM50195696
Synonyms:
(3S)-3-amino-3-{[(1S)-1-{[(2S)-2-[(2S)-butan-2-yl]-4-{2-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}-9-[(4-hydroxyphenyl)methyl]-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid | CHEMBL425077
Type:
Small organic molecule
Emp. Form.:
C46H60N10O10
Mol. Mass.:
913.0296
SMILES:
[#6]-[#6]-[#6@H](-[#6])-[#6@@H]-1-[#7]-c2c(-[#6]-c3ccc(-[#8])cc3)cc(-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#8])=O)cc2-[#6]-[#7](-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](-[#8])=O)-[#6]-1=O
Structure:
