Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50200163
Substrate
n/a
Meas. Tech.
ChEMBL_422555
Ki
2409±n/a nM
Citation
 Murineddu, G; Lazzari, P; Ruiu, S; Sanna, A; Loriga, G; Manca, I; Falzoi, M; Dessì, C; Curzu, MM; Chelucci, G; Pani, L; Pinna, GA Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem 49:7502-12 (2006) [PubMed]  Article  BDB Entry
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50200163
Synonyms:
1-(2',4'-dichlorophenyl)-6-methyl-N-phenyl-1,4-dihydroindeno-[1,2-c]pyrazole-3-carboxamide | CHEMBL385268
Type:
Small organic molecule
Emp. Form.:
C24H17Cl2N3O
Mol. Mass.:
434.317
SMILES:
Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)Nc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: