Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13017
Substrate
n/a
Meas. Tech.
ChEMBL_430874 (CHEMBL913943)
Ki
120±n/a nM
Citation
 Wu, Q; Gee, CL; Lin, F; Tyndall, JD; Martin, JL; Grunewald, GL; McLeish, MJ Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem 48:7243-52 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Human
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM13017
Synonyms:
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHEMBL26717 | SKF 29661
Type:
Small organic molecule
Emp. Form.:
C9H12N2O2S
Mol. Mass.:
212.269
SMILES:
NS(=O)(=O)c1ccc2CCNCc2c1
Structure:
Search PDB for entries with ligand similarity: