Reaction Details Report a problem with these data
Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50177110
Substrate
n/a
Meas. Tech.
ChEMBL_431029 (CHEMBL915899)
IC50
132±n/a nM
Citation
 Kotturi, SV; Jiang, S; Chang, AC; Abraham, P; Navarro, HA; Kuhar, MJ; Carroll, FI Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes. J Med Chem 48:7437-44 (2005) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | SC6A2_HUMAN | SLC6A2 | NAT1 | NET1 | SLC6A5 | Monoamine transporter
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Human
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50177110
Synonyms:
2-beta-(4-fluorophenyl)-3-beta-(4-methylphenyl)tropane | CHEMBL225235
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: