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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50217377
Substrate
n/a
Meas. Tech.
ChEMBL_437311 (CHEMBL906711)
IC50
349300±n/a nM
Citation
 Gökhan-Kelekçi, N; Yabanoglu, S; Küpeli, E; Salgin, U; Ozgen, O; Uçar, G; Yesilada, E; Kendi, E; Yesilada, A; Bilgin, AA A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics. Bioorg Med Chem 15:5775-86 (2007) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
Monoamine oxidase B (rMAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase-B (MAO-B) | Amine oxidase [flavin-containing] B | Amine oxidase (flavin-containing) B | Monoamine oxidase type B (MAOB) | AOFB_RAT | Maob | Monoamine Oxidase Type B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rat
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50217377
Synonyms:
N-methyl-5-(1H-pyrrol-2-yl)-3-p-tolyl-4,5-dihydropyrazole-1-carbothioamide | CHEMBL389866
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: