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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50215120
Substrate
n/a
Meas. Tech.
ChEMBL_456459 (CHEMBL887280)
EC50
50±n/a nM
Citation
 Pettersson, I; Ebdrup, S; Havranek, M; Pihera, P; Korínek, M; Mogensen, JP; Jeppesen, CB; Johansson, E; Sauerberg, P Design of a partial PPARdelta agonist. Bioorg Med Chem Lett 17:4625-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50215120
Synonyms:
2-(2-methyl-4-(2-(3-morpholinoprop-1-ynyl)-6-(2-(4-(trifluoromethyl)phenyl)ethynyl)pyridin-4-ylthio)phenoxy)acetic acid | CHEMBL250673
Type:
Small organic molecule
Emp. Form.:
C30H25F3N2O4S
Mol. Mass.:
566.591
SMILES:
Cc1cc(Sc2cc(nc(c2)C#Cc2ccc(cc2)C(F)(F)F)C#CCN2CCOCC2)ccc1OCC(O)=O
Structure:
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