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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50176263
Substrate
n/a
Meas. Tech.
ChEMBL_464100 (CHEMBL948141)
IC50
>10000±n/a nM
Citation
 Shao, L; Hewitt, M; Jerussi, TP; Wu, F; Malcolm, S; Grover, P; Fang, K; Koch, P; Senanayake, C; Bhongle, N; Ribe, S; Bakale, R; Currie, M In vitro and in vivo evaluation of O-alkyl derivatives of tramadol. Bioorg Med Chem Lett 18:1674-80 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | SC6A2_HUMAN | SLC6A2 | NAT1 | NET1 | SLC6A5 | Monoamine transporter
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Human
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50176263
Synonyms:
CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol | Ultracet | 3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol | O-DESMETHYL TRAMADOL
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
249.17
SMILES:
CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1 |r|
Structure:
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