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Target
Thromboxane-A synthase
Ligand
BDBM50227631
Substrate
n/a
Meas. Tech.
ChEMBL_465386 (CHEMBL945934)
IC50
3000±n/a nM
Citation
 Côté, B; Boulet, L; Brideau, C; Claveau, D; Ethier, D; Frenette, R; Gagnon, M; Giroux, A; Guay, J; Guiral, S; Mancini, J; Martins, E; Massé, F; Méthot, N; Riendeau, D; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett 17:6816-20 (2008) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Thromboxane Alpha | Thromboxane synthase | Thromboxane-A synthase | TXA synthase | Thromboxane A2 Synthase | P450 TxA2 | Thromboxane prostanoid | Cytochrome P450 5A1 | TXS | THAS_HUMAN | TBXAS1 | CYP5 | CYP5A1 | TXAS | Thromboxane A2 Synthase (P450 TxA2)
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Human
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50227631
Synonyms:
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: