Target
Isoprenyl transferase
Ligand
BDBM50372759
Substrate
n/a
Meas. Tech.
ChEMBL_465860 (CHEMBL951083)
IC50
800±n/a nM
Citation
 Peukert, SSun, YZhang, RHurley, BSabio, MShen, XGray, CDzink-Fox, JTao, JCebula, RWattanasin, S Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorg Med Chem Lett 18:1840-4 (2008) [PubMed]  Article 
Target
Name:
Isoprenyl transferase
Synonyms:
Di-trans,poly-cis-decaprenylcistransferase | Ditrans,polycis-undecaprenyl-diphosphate synthase | ISPT_STRPN | UDS | UPP synthase | Undecaprenyl diphosphate synthase | Undecaprenyl pyrophosphate synthase | uppS
Type:
PROTEIN
Mol. Mass.:
28705.02
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_465860
Residue:
252
Sequence:
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV
  
Inhibitor
Name:
BDBM50372759
Synonyms:
CHEMBL256476
Type:
Small organic molecule
Emp. Form.:
C24H27N3O3
Mol. Mass.:
405.4895
SMILES:
O=C(Nc1ccc(cc1)N1CCCCC1)C1C(=O)NC(CCc2ccccc2)C1=O
Structure:
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