Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM12581
Substrate
n/a
Meas. Tech.
ChEMBL_466620 (CHEMBL924794)
Ki
55.9±n/a nM
Citation
 Dunford, JE; Kwaasi, AA; Rogers, MJ; Barnett, BL; Ebetino, FH; Russell, RG; Oppermann, U; Kavanagh, KL Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem 51:2187-95 (2008) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Farnesyl pyrophosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthetase | Dimethylallyltranstransferase | Geranyltranstransferase | Farnesyl diphosphate synthase (FPPS) | FPP synthetase | FPP synthase | P14324 | FPPS_HUMAN | FDPS | FPS | KIAA1293 | Farnesyl diphosphate synthase
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Human
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM12581
Synonyms:
JMC515594 Compound 62 | (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid | CHEMBL834 | Bisphosphonate 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: