Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50088426
Substrate
n/a
Meas. Tech.
ChEMBL_466721 (CHEMBL937442)
IC50
57000±n/a nM
Citation
 Ando, T; Iwata, M; Zulfiqar, F; Miyamoto, T; Nakanishi, M; Kitade, Y Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem 16:3809-15 (2008) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AdoHcyase | PfSAHH | S-adenosyl-L-homocysteine hydrolase | SAHH_PLAF7
Type:
PROTEIN
Mol. Mass.:
53833.80
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_196715
Residue:
479
Sequence:
MVENKSKVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECALLIETLQKLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTWGDGDDNGPDMIVDDGGDATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSILKNPKKWTNIAKKIIGVSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSLPDGLMRATDFLISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNVVTLDEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKGIHIENVKPQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQNKDTNKYENKVYLLPKHLDEKVALYHLKKLNASLTELDDNQCQFLGVNKSGPFKSNEYRY
  
Inhibitor
Name:
BDBM50088426
Synonyms:
3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentane-1,2-diol | (1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol | CHEMBL49935
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: