Target
Melanocortin receptor 3
Ligand
BDBM50373479
Substrate
n/a
Meas. Tech.
ChEMBL_467903 (CHEMBL925937)
IC50
4293±n/a nM
Citation
 Guo, LYe, ZUjjainwalla, FSings, HLSebhat, IKHuber, JWeinberg, DHTang, RMacNeil, TTamvakopoulos, CPeng, QMacIntyre, Evan der Ploeg, LHGoulet, MTWyvratt, MJNargund, RP Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators. Bioorg Med Chem Lett 18:3242-7 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50373479
Synonyms:
CHEMBL254757
Type:
Small organic molecule
Emp. Form.:
C31H40Cl3N3O2
Mol. Mass.:
593.027
SMILES:
CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(Cl)cc1Cl)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: