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Target
Pituitary adenylate cyclase-activating polypeptide type I receptor
Ligand
BDBM50374178
Substrate
n/a
Meas. Tech.
ChEMBL_469030 (CHEMBL949341)
Ki
85±n/a nM
Citation
 Beebe, X; Darczak, D; Davis-Taber, RA; Uchic, ME; Scott, VE; Jarvis, MF; Stewart, AO Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R). Bioorg Med Chem Lett 18:2162-6 (2008) [PubMed]  Article 
Target
Name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Synonyms:
ADCYAP1R1 | PACR_HUMAN
Type:
PROTEIN
Mol. Mass.:
53307.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_498617
Residue:
468
Sequence:
MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
  
Inhibitor
Name:
BDBM50374178
Synonyms:
CHEMBL411120
Type:
Small organic molecule
Emp. Form.:
C24H17ClF3N3O2
Mol. Mass.:
471.859
SMILES:
Oc1ccc(cc1Cl)C(=O)N\N=C\c1cccc2n(Cc3cccc(c3)C(F)(F)F)ccc12
Structure:
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