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Target
Coagulation factor X
Ligand
BDBM50374261
Substrate
n/a
Meas. Tech.
ChEMBL_469192 (CHEMBL932218)
Ki
16.4±n/a nM
Citation
 Young, RJ; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Charbaut, M; Convery, MA; Diallo, H; Hortense, E; Irving, WR; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Pateman, AJ; Patikis, AN; Pinto, IL; Pollard, DR; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Zhou, P Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg Med Chem Lett 18:28-33 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | FA10_HUMAN | F10
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50374261
Synonyms:
CHEMBL270431
Type:
Small organic molecule
Emp. Form.:
C24 H24 Cl F2 N5 O3 S2
Mol. Mass.:
n/a
SMILES:
FC1CCN(Cc2nccn2-c2ccc(N3CCC(NS(=O)(=O)\C=C\c4ccc(Cl)s4)C3=O)c(F)c2)C1 |w:18.19,1.0|
Structure:
Search PDB for entries with ligand similarity: