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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50009859
Substrate
n/a
Meas. Tech.
ChEMBL_550432 (CHEMBL1003454)
IC50
18000±n/a nM
Citation
 Ringbom, T; Segura, L; Noreen, Y; Perera, P; Bohlin, L Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61:1212-5 (1998) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | Prostaglandin G/H synthase (cyclooxygenase) | PGH1_HUMAN | PTGS1 | COX1
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Human
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50009859
Synonyms:
(RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)propanoic acid | (+-)-p-isobutylhydratropic acid | (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid | alpha-(4-isobutylphenyl)propionic acid | 4-isobutylhydratropic acid | Advil | 2-[4-(2-methylpropyl)phenyl]propanoic acid | alpha-(p-isobutylphenyl)propionic acid | Motrin | (+-)-ibuprofen | (4-isobutylphenyl)-alpha-methylacetic acid | (+-)-2-(p-isobutylphenyl)propionic acid | IBUPROFEN LYSINE | Ibuprofen | Brufen | Ibuprofen (1)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)Cc1ccc(cc1)[C@H](C)C(=O)O
Structure:
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