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Target
Aspartate-semialdehyde dehydrogenase
Ligand
BDBM50377941
Substrate
n/a
Meas. Tech.
ChEMBL_550047 (CHEMBL1003381)
IC50
306000±n/a nM
Citation
 Carroll, AR; Ngo, A; Quinn, RJ; Redburn, J; Hooper, JN Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp. J Nat Prod 68:804-6 (2005) [PubMed]  Article 
Target
Name:
Aspartate-semialdehyde dehydrogenase
Synonyms:
DHAS_HELPY | asd
Type:
PROTEIN
Mol. Mass.:
38120.98
Organism:
Helicobacter pylori
Description:
ChEMBL_550047
Residue:
346
Sequence:
MKTYNVAIVGASGAVGQELIKGLENSFFPIKKFVPLASTRSAGKKIKAFNKDYEILETTHEVFEREKIDIAFFSAGGSVSEEFATSASKTALVVDNTSFFRLNKDVPLVVPEINAKEIFNAPLNIIANPNCSTIQMTQILNPLHLHFKIKSVIVSTYQAVSGAGNKGIESLKNELKTALECLEKDPTIDLNQVLQAGAFAYPIAFNAIAHIDTFKENGYTKEELKMLHETHKIMGVDFPISATCVRVPVLRSHSESLSIAFEKEFDLKEVYEVLKNAPSVAVCDDPSHNLYPTPLKASHTDSVFIGRLRKDLFDKKTLHGFCVADQLRVGAATNALKIALHYIKNA
  
Inhibitor
Name:
BDBM50377941
Synonyms:
PETROSAMINE B
Type:
Small organic molecule
Emp. Form.:
C21H18BrN3O2
Mol. Mass.:
424.289
SMILES:
Cn1ccc2c(c1)c(=[OH+])c1c3c(C(=O)C[N+]1(C)C)c1cc(Br)ccc1nc23
Structure:
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