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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50250509
Substrate
n/a
Meas. Tech.
ChEMBL_547440 (CHEMBL1029255)
IC50
97000±n/a nM
Citation
 Noreen, Y; el-Seedi, H; Perera, P; Bohlin, L Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. J Nat Prod 61:8-12 (1998) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
Cyclooxygenase-1 | PGH1_BOVIN | PTGS1 | COX-1 | COX1 | Cyclooxygenase
Type:
PROTEIN
Mol. Mass.:
68814.10
Organism:
Bovine
Description:
ChEMBL_547440
Residue:
600
Sequence:
MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVRSNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMVYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50250509
Synonyms:
5,3'-dihydroxy-7,4',5'-trimethoxyisoflavone | CHEMBL504481
Type:
Small organic molecule
Emp. Form.:
C17H14O7
Mol. Mass.:
330.07
SMILES:
COc1cc(cc(O)c1OC)-c1coc2cc(O)cc(O)c2c1=O
Structure:
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