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Target
Prostaglandin G/H synthase 1
Ligand
BDBM17638
Substrate
n/a
Meas. Tech.
ChEMBL_547440 (CHEMBL1029255)
IC50
1100±n/a nM
Citation
 Noreen, Y; el-Seedi, H; Perera, P; Bohlin, L Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. J Nat Prod 61:8-12 (1998) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
Cyclooxygenase-1 | PGH1_BOVIN | PTGS1 | COX-1 | COX1 | Cyclooxygenase
Type:
PROTEIN
Mol. Mass.:
68814.10
Organism:
Bovine
Description:
ChEMBL_547440
Residue:
600
Sequence:
MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVRSNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMVYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
  
Inhibitor
Name:
BDBM17638
Synonyms:
indometacin | Indocin | 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid | CHEMBL6 | Indomethacin | US9271961, Indomethacin | US11478464, Compound Indomethacin | US11786535, Compound Indomethacin
Type:
Small organic molecule
Emp. Form.:
C19H16ClNO4
Mol. Mass.:
357.08
SMILES:
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
Structure:
Search PDB for entries with ligand similarity: