Target
B1 bradykinin receptor
Ligand
BDBM50243345
Substrate
n/a
Meas. Tech.
ChEMBL_487377 (CHEMBL1021904)
Ki
2.10±n/a nM
Citation
 Su, DSLim, JLTinney, EWan, BLMurphy, KLReiss, DRHarrell, CMO'Malley, SSRansom, RWChang, RSPettibone, DJYu, JTang, CPrueksaritanont, TFreidinger, RMBock, MGAnthony, NJ 2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists. J Med Chem 51:3946-52 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50243345
Synonyms:
CHEMBL451761 | Tetrahydrofuran-2-ylmethyl{4-[({2-[(5-fluoropyridin-2-yl)carbonyl]phenyl}amino)sulfonyl]phenyl}carbamate
Type:
Small organic molecule
Emp. Form.:
C24H22FN3O6S
Mol. Mass.:
499.511
SMILES:
Fc1ccc(nc1)C(=O)c1ccccc1NS(=O)(=O)c1ccc(NC(=O)OCC2CCCO2)cc1
Structure:
Search PDB for entries with ligand similarity: