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Target
Interstitial collagenase
Ligand
BDBM50247788
Substrate
n/a
Meas. Tech.
ChEMBL_495058 (CHEMBL1003630)
IC50
6±n/a nM
Citation
 DasGupta, S; Murumkar, PR; Giridhar, R; Yadav, MR Current perspective of TACE inhibitors: a review. Bioorg Med Chem 17:444-59 (2009) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
Fibroblast collagenase | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) | MMP1_HUMAN | MMP1 | CLG
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Human
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50247788
Synonyms:
(2R,3S)-N1-((S)-3-(4-guanidinophenyl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutyl-3-(3-phenylpropyl)succinamide | CHEMBL516206
Type:
Small organic molecule
Emp. Form.:
C28H12N6O4
Mol. Mass.:
496.09
SMILES:
[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#6@H](-[#6]-[#6]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#8] |r|
Structure:
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