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Target
Corticotropin releasing hormone receptor 2
Ligand
BDBM50293910
Substrate
n/a
Meas. Tech.
ChEMBL_572724 (CHEMBL1030148)
IC50
>10000±n/a nM
Citation
 Hartz, RA; Ahuja, VT; Rafalski, M; Schmitz, WD; Brenner, AB; Denhart, DJ; Ditta, JL; Deskus, JA; Yue, EW; Arvanitis, AG; Lelas, S; Li, YW; Molski, TF; Wong, H; Grace, JE; Lentz, KA; Li, J; Lodge, NJ; Zaczek, R; Combs, AP; Olson, RE; Mattson, RJ; Bronson, JJ; Macor, JE In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. J Med Chem 52:4161-72 (2009) [PubMed]  Article 
Target
Name:
Corticotropin releasing hormone receptor 2
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
47765.85
Organism:
Pig
Description:
ChEMBL_572724
Residue:
411
Sequence:
MDAALLHSLLEANCSLALAEELLLDGWGMSLDPEGRYFYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLIFLALRSIRCLRNVIHWNLIATFILRNVLWFLLQLIDHEVHESNEVWCRCITTVFNYFVVTNFFWMFAEGCYLHTAIVMTYSTERLRKWLFLFIGWCVPCPIIIAWAIGKLYYENKQCWFGKEPGDLVDYIYQGPIILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVSPGEDELSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAAVRKRWHRWQDHHSLRVPVARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM50293910
Synonyms:
(S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichloro-4-(difluoromethoxy)phenylamino)pyrazin-2(1H)-one | CHEMBL562219
Type:
Small organic molecule
Emp. Form.:
C16 H14 Cl3 F2 N3 O2
Mol. Mass.:
424.65706
SMILES:
C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O |r|
Structure:
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