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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50294422
Substrate
n/a
Meas. Tech.
ChEMBL_575368 (CHEMBL1027042)
Kd
880±n/a nM
Citation
 Jiang, S; Liao, C; Bindu, L; Yin, B; Worthy, KW; Fisher, RJ; Burke, TR; Nicklaus, MC; Roller, PP Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg Med Chem Lett 19:2693-8 (2009) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50294422
Synonyms:
4-{[(9S,15R,18S,21S)-15-carbamoyl-21-(carbamoylmethyl)-3,3,8,11,17,20,23-heptaoxo-18-(propan-2-yl)-3,13-dithia-7,10,16,19,22-pentaazaspiro[5.17]tricosan-9-yl]methyl}phenoxyphosphonic acid | CHEMBL552951
Type:
Small organic molecule
Emp. Form.:
C29H42N7O13PS2
Mol. Mass.:
791.787
SMILES:
CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCS(=O)(=O)CC2)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)CSC[C@H](NC1=O)C(N)=O |r|
Structure:
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